On my current med mix, with 600 mg Seroquel XR, I usually do manage to fall asleep, but before it or when the mania is more significant, I do have 1 or 3 am wake ups. When really manic, I have no desire to go back to sleep. I'm usually charged up and do something. However, I do sometimes go through phases when I wake up around 1 or 3 am and have racing thoughts, but am oddly physically tired. During those times I usually eat a yogurt and that helps, or if not, I put on my sound machine to rainfall, fire, or ocean