Spikes-I take metformin with my clozaril and it helped me stop gaining weight and then I've lost my clozaril weight plus 15 lbs. I don't know if the metformin helped with the actual weight loss since I have worked hard at that but it did make it possible for me to do the dieting and control the gain.

I think I also stopped gaining so much when I was on a dose for a long time and there were no more increases or adjustments for a long while.