I was on Zoloft 150mg for 17 years for dysthymia and generalized anxiety disorder. A few years ago, with the approval of my psychiatrist, I tapered off the Zoloft very slowly--over the course of 2 years. My depression and anxiety returned full force along with withdrawal symptoms. I had to increase the dose of the Zoloft to 200mg and add 1mg of Abilify and Klonopin as needed. It's more than a year and a half since reinstating the Zoloft, and I'm still not back to normal, even with the other meds. Please think carefully about the benefits and potential risks of discontinuing your medication. Here is an article by a psychiatrist who has seen many patients with severe SSRI withdrawal: How to Avoid Severe SSRI Withdrawal Symptoms? - Mad In America Even with extremely slow tapers, the withdrawal can be brutal and show up many months after the medication is discontinued. I'm not saying you should stay on your antidepressant, but just think carefully about why you're doing it and what the risks are. Talk to more than one psychiatrist if you can, and get as much information as possible from people who have discontinued their antidepressant--both successfully and unsuccessfully. Another online forum that you should check out is survivingantidepressants.org. If you do decide to taper, only do so under a psychiatrist's supervision, and I would make sure to get into therapy and have other coping mechanisms in place: start exercising regularly, eating right, limit caffeine and alcohol and other drugs, improve your stress management, make sure you're sleeping regularly, etc.