I never had the weight gain experience on Seroquel or Seroquel XR. However, one day I started acting "bizarrely" while on Seroquel XR and my pdoc had to increase my dose to knock me down. The problem was that I started to feel depressed shortly after increasing the dose (which my pdoc called a "manic crash"), so my pdoc bumped up the dose again and my depression became so severe that it was literally the worst depression I have ever had in my entire life. No exaggeration.

I had a strong hunch that Seroquel XR was causing problems for me. The depression vs Seroquel XR dosing was no coincidence because my depression slowly increased as the dose slowly increased. So once I got off that med, the depression went away almost instantly (within a few days, honestly). That med was poison for me, just like it was poison for you, except it was poison in a different way.

Well, Seroquel works very well for some people, but its potential side effects can be detrimental to our health and/or mental health. I agree that mental illness is so cruel.