Laurie, 125 lbs is indeed an extreme weight gain. Doesn't your psychiatrist consider this issue? My total weight gain while on Seroquel XR over the last 9 years has been 20 lbs, and I've recently lost almost 10 of it with diet and mood changes. I wonder if moods do play some part in some people's large weight gains in addition to a medication. It definitely does seem to be the case that some people react differently to different meds.

It is a possibility that my weight gain over the last 9 years had little to do with Seroquel XR. I'm getting older, chunkiness is in my family, and my activity levels have often been low. I was once around my current weight 16 years ago before I ever took a bipolar medication.

I did have large weight gain on Depakote and Invega, though was also depressed long-term on that combo. I will never take either of those meds again, not just because of weight gain, but other side effects from each, too.