Hello deb: I'm sorry I cannot comment with regard to your concern. However I noticed this is your first post here on PC. So... welcome to PsychCentral. Here's a link to a PsychCentral Professional article, from PC's archives, on the subject of L-Methylfolate. Perhaps some of the information in this article will be of some help:

L-Methylfolate for Depression: The Real Deal? | Psych Central Professional

Here are links to some other articles that offer tips on managing depression:

6 Steps for Beating Depression

10 Things I Do Every Day to Beat Depression

7 Ways to Manage Clinical Depression

9 Steps to Treat Depression Naturally

https://psychcentral.com/blog/taking...dium=popular17

https://psychcentral.com/blog/7-more...nd-medication/

Also... since you've clearly been dealing with depression for a long time, I'd also like to direct you attention to this other PsychCentral sponsored website for people who struggle with unrelenting depression & anxiety. (You may notice links to it in some of the articles above as well.)

http://community.projecthopeandbeyond.com/

I hope you find PC to be of benefit.