I've lost 25 lbs that mostly were gained on clozaril. I am on metformin but mostly that stopped me from gaining further weight after I gained 15 or 20 lbs in the first 8 months. A year ago I got serious about it, set a date and started a low glycemic index diet. I don't have to track what I eat in great detail with this, I just pay attention that I'm sticking to low and moderate GI foods and I lose weight. Not as easily as if I weren't on clozaril but I have lost 27 lbs in a year and that includes a few months I backed off and a few months that my diet was really weird because my gallbladder failed and I was very sick. I'm trying to lose 10 more lbs in the next month or 2 so that fall clothes from the past fit. I'm down 1.5 lbs this week so I'm on track again.

I also try to exercise 3-5 times per week, either a strenuous walk or low impact aerobics DVDs. That helps too.