I took Seroquel XR for a short time a few years ago and it pulled me out of a deep dark depression. It was like magic. I wish I could have stayed on it but it made me too tired. I didn’t fully wake up in the mornings until noon, after half my work day was over. I didn’t know at the time that regular release seroquel doesn’t have as much of a hangover in the morning or I would have asked to switch. I will definitely consider regular release seroquel if I ever get into a severe depression again and nothing else works.