I take regular Seroquel, 400 mg at night though I have 25 mg regular Seroquel to help in long panic attack situations. The low dose does help with panic though I have to take it only at home or when I don't have to drive. Sometimes it makes me sleepy and sometimes not.

I have had a positive experience with regular Seroquel but a negative experience with the extended release version. The XR Seroquel made me so tired, all I wanted to do was sleep all day, every day.

I take 400 mg of the regualar release Seroquel at night. It has helped curb mania for me. And it definitely knocks me out for sleep at night. Seroquel is the best med I've had for sleep that feels natural falling asleep. For me, it has not effected my weight at all. But I do exercise a lot and regularly. Though there were periods of time when I was on the higher dose and didn't exercise regularly such as most of last December, and when I did exercise then, it tended to be walking. December is just very busy for me. I did exercise in January, maybe I lost a couple pounds, I wasn't keeping track. I was just trying to tone my legs and core. Then, I definitely couldn't exercise while I was in the hospital (ulcer surgery) or 6 weeks during recovery. I lost weight, but that is normal with the surgery I had. I have kept losing weight on it, but at some point, I went from normal exercise to manic exercise, or maybe just the eating disorder.

I do know my old pdoc had me on 300 mg first until December. I can't remember how long I took it. Again, it was weight neutral, and if I was on that dosage for several months, it didn't affect my weight and did curb mania until I got manic again and the dosage was upped to 400 mg. For me, it is a lifesaver, especially for my problems with falling asleep.