Seroquel and depakote both have weight gain as a side effect. I wasn’t on seroquel long enough to gain weight but when I was up to 1750mg of depakote plus zyprexa (another weight gainer) I gained 20lb in six weeks. My dr lowered my depakote down to 1000mg and switched me off the zyprexa and I managed to lose about fifteen pounds over the next six months or so. I can’t seem to lose any more weight though. I don’t think I’ll ever be under 200lb again. I’ve made my peace with it for the most part.