I gained 22 lbs. on Lamictal of all things. Then the first time I went on Zyprexa in 2012, I ate like food was going out of style and gained 25 lbs. in six weeks. I was already obese so the extra pounds made things that much worse. But when I went back on Zyprexa for good in 2014, I didn't gain anything. Maybe it was because I was also on Geodon, which I think actually made me lose weight. I dropped 100 lbs. a couple of years later when my husband died and I lost my appetite for many months. I did put on a few pounds when my Zyprexa dose was increased this summer, but it's leveled off and my weight is stable.