Seroquel made me a zombie and made me gain a ton of weight. Prior to seroquel, I had never pulled the typical unruly psych/bipolar patient move and stopped taking my meds suddenly, but I did with Seroquel because I hated it so, so much. I have had a lot of success with Lamictal, which I started after I went off seroquel.
I should note, everyone has different experiences with every medication, though. It could always be worth a shot, but be wary of side effects.