Yes that would bother me a lot. I know very well how difficult it is to care about one's body during depression. However mentioning it will only make things much worse, making you even more ashamed. Personally, if someone in the past commented on my weight, I usually over ate in order to numb the shame and disgust. Another option was some short term unhealthy diet bordering on Ed. However since I've always been overweight /obese no one was bothered by my pathological relationship with food. Unfortunately slim people will never understand how hurtful and counterproductive their comments are.