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Old Oct 06, 2018, 10:11 AM
Anonymous35014
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Originally Posted by BirdDancer View Post
I'm happy to share my experiences with antipsychotics, but I really urge you to try new ones regardless of others' experiences. For example, you say you hate Seroquel, but my Seroquel XR has been my best antipsychotic yet. It has been effective at curbing and extinguishing many of my past depressions, manias, mixed states, and even anxiety, not to mention helping me sleep. It is the only antipsychotic that has yet to give me an EPS or hyperprolactinemia, besides Trilafon. The extended release Seroquel was fairly weight neutral for me up to 450 mg, but not as friendly at 600 mg plus, though not nearly as weight unfriendly as others. In the beginning of my Seroquel XR treatment, I had morning "hangovers", but that eased over time and by practicing certain strategies. Here are some of my other experiences:

* Seroquel regular - Less weight friendly than the XR. More sedating taking it twice per day vs. XR's evening only. Otherwise very helpful and no other side effects.

* Risperdal (risperidone) - Very effective for mania, agitation, and mixed. Gave me hyperprolactinemia. Some weight gain.

*Zyprexa - Very effective overall, but akathisia and rapid weight gain.

*Abilify - Weight friendly, but caused akathisia early on. On this combined with Lamictal, I felt marvelous for a few months, then the marvelous got way way out of hand! It turned full blown manic with psychosis, turning mixed with psychosis, resulting in one hospitalization followed by some serious out of hand behavior leading to another hospitalization for mania switching back and forth from euphoric to mixed with psychosis. It brought on the kindling effect leading to yet another hospitalization soon after.

*Invega - Only effective for mania, and very effective for that, but left me severely depressed. I gained a huge amount of weight on this med combined with Depakote. My cholesterol and triglycerides became very high, and became pre-diabetic. Like Risperdal, it gave me hyperprolactinemia. I also developed a pituitary microadenoma that this medication might have caused. Horrible!

*Geodon - Helpful for mania in the beginning, but the largest dose stopped being effective enough over time, so I needed a second antipsychotic added to curb breakthrough mania. I had at times been hypomanic for months straight before an adjunct was added. Then the full blowns started, necessitating one. Though helpful for sleep in the beginning, it stopped being helpful over time and I was up most of the night for a while. After 5 years, it started to cause terrible akathisia. When taken off this med (even slowly), I had rough withdrawals. This med was weight friendly for me. On it I had lost 40 lbs on a diet and maintained the weight loss for years until I was also taking higher doses of Seroquel XR.

*Navane (thiothixene) - A first generation AP. Helpful as an adjunct to Geodon and moodstabilizers. Was weight friendly. At 10 mg, I eventually developed a dystonia and had to go off.

*Trilafon (perphanazine) - Another 1st generation. Even more helpful than Navane as an adjunct to Geodon and moodstabilizers, but caused rapid weight gain at 12 mg.

The above are the only antipsychotics I've tried. I always took at least one moodstabilizer along with them (Lithium or an anticonvulsant).
Interesting experiences, BirdDancer.

Seroquel just gave me a bad hangover, and the XR just made me feel "blah"/flat until the dose was increased and it gave me depression. No weight gain here, either, although I only went up to 250mg of the XR before calling it quits because of the depression. Plus, it made my already-high cholesterol skyrocket.

I had the same experience on Abilify, minus the akathisia and severe mania. I had mania on it, but it doesn't sound as bad as yours. It also stopped helping my depression at some point. I'm just not sure if I hallucinated because of the mania or because I hallucinate all the time anyways. It's possible I was delusional, but I don't know and therefore don't remember, since it was so long ago.

Did you get heart problems on Geodon/Risperdal? I've heard of QT interval issues from a lot of people. A friend had rapid heartbeat on it and had to stop it.

Invega sounds interesting if it helps with mania. I don't think mania is my biggest issue, but psychosis is of course. I just hope it won't end up like Seroquel for me.

Now that I think of it, Zyprexa is olanzapine and Seroquel is quetiapine... I wonder if the "pine"s will have a negative affect on me...
Hugs from:
bizi