Quote:
Originally Posted by HopeForChange
So to my understanding, the -dones are all of the benzisoxazole structure, which is different from the benzodiazepine structure of the -pines. Aripiprazole is derived from a molecule with an azole group, among other things. Antifungals are, too, but the rest of the drug molecule (the part in addition to the azole ring) is very different
The differentiation between typicals and atypicals is based partly on when they were developed (atypicals are 2nd and 3rd generation antipsychotics, so came later). It's also based on the fact that atypicals have serotonergic activity in addition to dopaminergic activity, and therefore are theoretically better for negative symptoms in patients with schizophrenia (e.g. poor motivation, poor hygiene, lack of emotions, etc.). Personally I think typical vs. atypical aren't as separate of categories as they're made out to be, but that's just me, so take it with a grain of salt 
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Oh--to further confuse things, technically risperidone, iloperidone, and paliperidone are benzisoxazoles, while lurasidone and ziprasidone are benzisothiazoles. I think the distinction between the two structures isn't super significant, though