Thanks, everyone! Yesterday my psychiatrist lowered my Seroquel XR from 600 to 500 mgs. That's his usual strategy when I'm depressed in a low energy numb kind of way. He only increases my dose if I'm some level of manic, in a mixed state, or depressed with agitation. I've got to say that taking only 500 mg last night has already made a slight difference. I took it right before my adult school class at 7 pm, and unlike lately when I've fallen asleep at 8 or 9 pm and struggled to get up, I was plenty awake until about 10:30 pm last night and managed to get to the phlebotomist at 7 am ish this morning. I even feel noticably better right now. Was that extra Seroquel XR really just too sedating to the point of lowering my mood, or was my success at the class a factor?