I take seroquel for sleep and also feel groggy in the mornings. What my pdoc and I have done is to lower the dose to the absolute lowest possible that still puts me to sleep (25 mgs). I have to perform good "sleep hygiene"... meaning I set a bedtime and stick to it; I also stick to a set time to get up, whether I feel like being awake or not...I must get out of bed and start moving around. The grogginess wears off faster if I start moving around...I also take wellbutrin in the morning which has a tendancy to amp people up. Basically, on seroquel I sleep 9 hours if I just sleep with no alarm and nowhere to be...however, I am groggy if I sleep 9 hours or 7 hours. I know this, so I act accordingly...I'm in bed by 9 and set my alarm for 5:30. This gives me an extra half an hour to move around slowly and let the grogginess disipate. The early bedtime sucks a bit, but tivo helps...as does knowing that I am going to sleep (thanks to seroquel) and therefore I will be able to function. It's an understatement to say I don't function well without sleep!