I was never on zyprexa but I have read that it is one of the worst when it comes to weight gain. I was on seroquel but I can’t remember when I went off it. I was very sick at the time and I was only 13 and 14. I had no say in what I was taking and I was gaining a lot from everything. Doctors and nurses didn’t take my weight gain concerns seriously at all. I was being put on meds and taken off them weeks later without them being given a chance. So I either went from 118-130 on Seroquel or 130-160 on it. But I can’t remember.