I went extremely manic on wellbutrin alone as well last year to the point that I almost killed myself because I was so happy? Lol Anyways Im on 150mg now instead of 300 plus the lithium and depakote and have had no manic symptoms at all. Last time they cut the dose to 150 and put me on depakote and risperidone as well to try to stop the mania first but had to take me off the wellbutrin completely so I believe the lithium must be helping more with that this time.