I was on Seroquel for a long time (9 years?) and it really helped me. I was on really high doses most of that time; 800 mg for a long time and eventually 1200 mg and then 1500 mg. The last 2 are higher than recommended but the hospital where I see my pdoc feels comfortable with that in certain circumstances.

I gained a little weight but nothing drastic. I could probably have avoided that with a healthier diet at the time.