I take Clozaril in conjunction with an antidepressant (Pristiq). The Clozaril makes me feel much less hyped up during the day and I actually fall asleep at night (I take 100mg in the morning 200mg at night). It definitely works better than lithium or other mood stabilizers in that it keeps me from having full blown psychosis, lithium would just keep me from going manic but I would still have hallucinations and delusions and such. So yeah, it helps with mania and psychosis, but not enough with depression to not need an antidepressant.