I take Seroquel with Wellbutrin and Lamictal. For me, it's been a lifesaver and has helped a lot with mania (sleep too). Lots of people are very tired on it or gain weight, but everyone is different; Seroquel has been weight neutral for me though I do exercise a lot. However, before that, the pdoc tried me on extended release Seroquel, and I was a mess. I only wanted to sleep, eat when I needed to. I had no energy to exercise at all. I just couldn't function. Can't say about weight; I think I was on it less than 2 weeks when I called and told her I just couldn't function on it; then she tried me on the regular release and I was fine.

I took Abilify quite some time, but I don't think it did a thing for me.

I don't know with Lamictal if I really feel anything taking it though maybe it stops the moods swinging back and forth so much?

The Seroquel helps with the mania, the Wellbutrin with the depression. I haven't had bad mania lately, so maybe the Seroquel is helping. On the other hand, I've been mixed forever, and that is no fun either. The Wellbutrin maybe gives me energy, at least sometimes. IDK, maybe stress, things like that factor into it.