As Wild Coyote said meds are definitely different for each individual, but i will give you my thoughts; I have been on a Antipsychotic alone for most of treatment. Seroquel really does do the trick at least for me. I had such a bad reaction to a few big name Antidepressants that I think my doctor is afraid to combine the too, even though the Seroquel would probably balance it out. I've also had a reaction to a few other Antipsychotics. I was on Lamictal alone for a few days, but while I was on it I was withdrawing from Effexor and the NP I was seeing at the time didn't tell me that what I was feeling was probably Effexor withdraw and not a reaction to the Lamictal like she thought. I haven't been brave enough to try Lamictal alone again, so I stick with the Seroquel and the Buspar since I at least know these work.