I'm so sorry you're struggling, spikes It's always important to be careful with meds. At this point I don't know what to suggest... if you keep taking 50mg things may worse, but suddenly going to 300mg may be dangerous as well. How long have you been taking these meds? Are you sure you don't want to call earlier? It may be dangerous if you continue like this. I hope you'll see your Pdoc soon. Take care. Let us know how it goes. I'm so sorry you have to deal with this