I take the regular release Seroquel. When I'm stable, it's at around 300 mg. When I'm having manicky symptoms, they push it up. But I am on the mood stabilizer too, Lamictal. I was on the Lamictal alone for awhile then got very manic, and it was decided, nope, it wasn't bipolar II, it was bipolar I, and I was put on Seroquel. But the pdoc tried me on the extended release version first, and it was awful for me. I was so tired, I just wanted to sleep all day (not even necessarily from being depressed, just very sleepy). I'm on Seroquel 500 mg, but it's making me too tired; called my pdoc, we are going to try 450 mg. I was a 400 mg but leaning toward the manicky side of mixed, I guess?