I have been taking Adderall for treatment resistant depression for about 8 years and it does help my depression. I also take Cymbalta and bupropion. My previous psychiatrist gave it to me when I started working 12 hour shifts so I could keep working. Now my new psychiatrist wants to wean me off of it since I don't have ADHD and my blood pressure is up. I have weaned down the dose but my depression is also not controlled as well. It is a pain to have to take a paper copy RX to the pharmacy each month, but I do believe it really helps my depression.