One thing that I've learned with clozapine is that it can shut down that kind of mood shift. last summer I had a hypo day that was escalating rapidly toward manic and I emailed my pdoc at 3 AM begging to be allowed to up my dose for a few days to try to stop it (we're trying not to go higher for a daily dose because of sedation). One day stopped it. I was really groggy for 4 days and then stopped the med and the mania was gone and I did not get depressed or mixed. It's magical and nothing has ever done that for me before.