Only had one dose. Kept me up all night (literally, zero sleep) with the worst restless legs of my life. Also wobblieness, so I couldn't "walk it off". Not for me, but works for others. Everyone says the taste is terrible, but I dunno. If you can handle that numbing Chloroseptic throat spray, you can handle the taste of Saphris, lol. Totally what it reminded me of.