I've been on it almost a year. When i started it at 7.5m it was so sedating it literally floored me, like sleeping on the ground floored. It also increased appetite a bit. As I went up to 30m, all that went away. I asked my pdoc and he said that's very common. In fact he said people that do the small dose tend to have the sedation especially, and people that go to the max dose actually have no sedation at all. I cant say it has helped much with depression for me. I want to get off of it actually as i'm not sure its doing anything at this point.