I'm on two thyroid medications for psychiatric reasons only. My thyroid function is WNL for general purposes but my pdoc subscribes to Dr. Phelps' theory, and so far it's worked pretty well. No depression at all last winter. I went on the second med when my depression came back this winter, but I'm pulling out of it so I have to give the liothyronine some credit. None of my other meds have changed in almost three years except for the Zyprexa, which went up a bit last summer.