No, I've never taken a break from them. I went off Invega a year ago because of developing tardive diskinesia, which went away after I was off it for awhile but I've been on all my other meds still. Mood stabilizer, andtidepressants, seroquel at night for sleep etc. I was crying because I was trying to heat something up in the microwave and was confused and irritated that I couldn't figure it out for a couple minutes like I forgot how to use it, I don't know what's going on