Sorry you're feeling awful, Momof2since2004.

Depression can be so tough!
Have you ever tried guided meditation?
What about a volunteer opportunity? A way to meaningfully connect with others. There is research indicating that being part of a group and helping others can help to ameliorate depression and loneliness.
Could it be time to try a new doctor? Or a psychologist? To develop coping strategies and gain some empathetic comfort?
If you feel that things are good with your husband in other ways, it could be that he truly doesn't understand depression and doesn't know how to help. That's different from not caring though I fully understand why you would feel alienated and lonely.
What about picking one day a week when you and the children (hub too if he wants) do something together instead of playing video games? Play a board game or watch a film or play cards or do a puzzle or art activity together?
Peace and hope to you.