As far as work, work is work, sometimes quirky ambitions rule the roost. Cruddy to deal with, but easier to bounce back from the annoyances of work than those gut wrenching lost friendships.
Of course you're hurt.

One takes off and doesn't respond to your checking in? I mean, yeah, what was that all about?
With the other, cuts ties after marriage?
Are they both running from themselves or something? Because, that's my only conclusion.
I'm so sorry that you're going through this. It is painful. Be gentle and kind to yourself. Grieve the loss. Don't let them dictate your worth. I don't believe that it's you for a minute, it's them.