I have been on and off Seroquel about 5 times. We go off because of weight gain but then end up back on it because nothing else works. I am the heaviest I have ever been. It is so depressing. I get out of breath just walking to my car. Unfortunately I can’t take antidepressants so we have to get creative with my treatment. I am finishing up a course of ketamine so maybe I will be able to come off it soon.