Hi bizi. When I've been taking the prn Seroquel lately, it's usually because of extreme agitation (agitation being a mild word). If I take it for that (usually 50 mg regular Seroquel), it usually does calm my agitation within about 30 minutes. That kind of dose during such times doesn't make me at all tired, though. The thing is, this agitation seems to show up at some times almost every day lately. I try to avoid taking the prn (sometimes the agitation eases without), but it's been a lot lately. Really, it's possible that a 50 mg daily increase of my daily Seroquel XR dose might be a good idea so the need for regular Seroquel prns can stop. I wouldn't normally mind, but I have been really eating a lot lately. I think the overeating is partly because of my recent mood issues, and partly because of my Seroquel XR dose. It's hard for me to lose weight taking any more than 450 mg of Seroquel XR daily. I'm now on 500 mg. It often goes up to 600 mg (or more) at times.

Usually I'm not that concerned about my weight, but it has been steadily going up up up over the past months. I am really afraid that I will eventually reach my all time high weight. When I was at that weight, my blood work was particularly bad. I don't want to get diabetes. My sister got diabetes. Diabetes is common in my family.