I too have such feelings of emptiness, that come and go all the time. Like LadyShadow and KD1980 I try doing things that make me feel more fulfilled. Oftentimes the emptiness is accompanied by feelings of either apathy or inadequacy. If it's apathy I try things that will raise my energy like listening to upbeat music, dancing, playing with our dog, or certain types of meditation. If I'm feeling useless then I'll try getting immersed in a project (I love researching family history and history of NYC), organizing and cleaning, or gardening. At some level though I've always felt empty, even during the best times. I too wonder if it's because of past childhood experiences.