Thanks so much, pat86! I would love if my carb cravings were reduced. It is really the carbs that are my most serious eating challenge. If my urges and appetite could be reduced, I could then diet. I know that if I diet, even on 550 mg Seroquel XR, I can lose weight. Last year I went from 174 lbs to 167 lbs between April and July. I was very happy with that, but then I had mood issues that made the dieting difficult again. When I have major carb cravings I just can't diet.

9.5 years ago I reached my all-time high of 192 lbs. That was a rough time for me mood-wise and my medication mix was very weight unfriendly. I was then put on a rather weight friendly mix (Lithium was weight friendly) and lost 40 lbs in six months. That took me down to 152 lbs, which is actually a great weight for me. I look pretty trim at that weight, and it's a normal BMI weight. I maintained the weight loss for a good four years before my Seroquel XR dose went up. I stayed within 15 lbs of that low for another two years, then my Seroquel XR went even higher and it became difficult not to gain weight.

My psychiatrist says he might try a new antipsychotic. We'll see if that happens. If it is a weight friendly one, I'll have a good chance of losing weight because of that, too.

My glucose level hasn't been that high, but my cholesterol (especially) and triglycerides have been high for years other than when I lost that 40 lbs I mentioned.

Thanks for the tip about the XR version of Metformin. If my psychiatrist does prescribe it, I'll ask for the XR. I generally always do better on extended release versions of medications.