I've lost 30 pounds while on clozaril thanks in part to metformin (this is all the weight I gained on clozaril and some of the weight from my prior AP Seroquel). My glucose levels have gone from borderline to normal and I no longer have metabolic syndrome. My A1C is really low. My family dr offered to take my off it but I think it is better to stay on it since so much improved. It did take 2 years to reach this point, mostly because the metabolic stuff happened after the weight loss.