Nowadays, very rarely unless I take my Seroquel XR too late at night and/or stay up too late. In the beginning, especially at higher doses, this was indeed an issue with my Seroquel XR. Time (getting used to that med) and figuring out the best times to take it and fall asleep improved that situation greatly. For me, taking my Seroquel XR no later than 8 pm (preferably 7 pm) and going to sleep by 11 pm or earlier (definitely no later than midnight) is best.

Q: What medication did you continue to take that you were glad you stuck with?