I've been on Latuda for 3 years. Overall, it's been a good med for me. Works better for depression than anything I've been on. I will say that when I first started it (and have had dosage changes), it kind of made me feel hypomanic for a bit. I also had BAD irritability for a couple weeks in the beginning. I did level out though after a few weeks. The dosage increase wasn't as bad as when I started it. Other than that, I really haven't had any side effects and it's been weight neutral.