I have bipolar type 1 and my manias tend to be pretty severe and psychotic. I was manic at the beginning of this year and then quickly transitioned into a deep depression so my pdoc started Latuda as well. I am still on a high dose of seroquel so I can’t exactly speak to that but I can tell you that she mentioned to me that 60 MG and above of Latuda start to hit on the mania as well as the depression. I currently take 40 MG of Latuda and I must admit it worked pretty quickly and quite well against my depression and has not, for me, been overly activating.