xRavenx, perhaps you recall that I now take Seroquel XR (600 mg) with a starter dose if Latuda (20 mg), plus others. It's too soon for me to know how they'll work together, but I have no complaints after two Latuda doses.

I think that ideally it is good to only need one antipsychotic, but sometimes more is what it takes. In the past, I took as many as three antipsychotics at the same time, along with other moodstabilizers. At that time I took a full dose of Geodon (160 mg), a small dose of Navane (5 mg), and maybe 150 to 350 mg Seroquel XR. I was being weaned off Navane and having my Seroquel XR dose increased.

I have needed fairly high doses of antipsychotics partly because I am vulnerable to mania and mixed states, and partly because my Tegretol XR (carbamazepine ER) affects their effectiveness, making me need more. If a highest recommended or tolerated dose (i.e. Geodon 160 mg) doesn't do the full job, I need a second one.