I have been on latuda for quite some time now. Out of everything that I have taken, it has made me the most stable. I take it with adderall and trileptal. When I started to gain weight, i was placed on naltrexone, which helps for the most part. I stay pretty low and when i complained about it, my pdoc reduced my dosage to 40 from 60. I definitely have not had trouble with latuda causing manic symptoms.