I have been through almost all the atypical antipsychotics and many mood stabilizers over the last 14 years. My current (and longest) psych nurse practitioner says I am a difficult case- that I have severe bipolar 1 disorder- that I'm hard to treat. I sort of have a coctail that works now, though we use Haldol sparingly for acute episodes. (Just out of mania, right now.) Its not about how many but about what works- or doesn't- for you. I have had so many bad side effects to meds! Glad to be on something that works at the moment.