Sorry that I'm late to responding again to this... thanks for your input and for sharing your experiences! So far, I am not noticing anything significant on Latuda with Seroquel, except sometimes I wake up in the middle of the night. But it's only for a brief second (strangely, like being shaken out of sleep... not sure if I'm describing it accurately), but then I go right back to sleep. I'm not even 100% sure if that's due to the Latuda, but that's when I noticed it. However, I don't think it's a real concern. I think the 2 AP's are definitely needed at this time for me, because I felt some relief after the add-on and Seroquel is the one medication that helps me with sleep. Hopefully, this will continue.