I have familial hypocholesterolemia, but Seroquel XR exacerbated it. My GP warned me that Seroquel was dangerous for me, even though my pdoc didn't seem to believe that Seroquel was. (It was. I was getting labs every 2 months, and the cholesterol kept climbing. I've never weighed more than roughly 105 lb and I'm 5'4"/5'5" ish.) It was a sh_tty situation, and Seroquel makes me depressed at high enough doses anyways, so needless to say, Seroquel was tossed out.

I think latuda did the same thing to my cholesterol, but nowhere near as bad as what Seroquel did.