Hi chels. I have taken both immediate release and extended release. I've been taking the extended release for the last six years. It has been available in generic for me for about two years or so. The instant release generic is likely still cheaper for many people, though with good insurance the extended release generic is not that bad. I think I pay less than $30 in copays per 90-day supply, with my insurance.

I agree that your doctor should know which type of quetiapine (Seroquel) is best for your situation. I think the two types have similar advantages and disadvantages, but in my view have some differences that may make some a fan of one type over another. Experiences obviously vary. All I can say is that I, personally, clearly prefer the extended release quetiapine ER (Seroquel XR). In my particular case, the extended release is more weight "friendly" than the regular instant release. Also, it has been particularly helpful for not only my mania control, but also bipolar depression, anxiety, and sleep. Unlike other antipsychotics, I have not experienced any EPS or hyperprolactinemia on Seroquel.

The tough part for me with both Seroquels was the initial sedation issues, when not manic. Having been on Seroquel XR for a long while, that did eventually ease, but it required patience, tolerance, and strategy. By strategy, I mean taking it at a particular time, going to sleep no later than certain times, and creating a wake up time ritual. If I take it too late, stay up too late, and wake up too early, I sometimes still get what many people call a "Seroquel hangover". If I don't, I don't.