There is evidence that alternatives do help the brain, as alternatives for the general purpose for the brain. Example, using sugar to give a sugar high for the brain function that gives a short term enjoyment and brain activity. Is there evidence that a alternative that can only help the brain of someone who has a bipolar disorder -- the empirical evidence is critically lacking for or against.

There is evidence with the differences with a female brain and a male brain. There is critical mass of people who have a bipolar disorder, a smaller mass who are in treatment, and a smaller mass who would be interested in a long term study of alternative medications. There is very little interest to give a grant to study alternative medications on bipolar subjects, and to study the differences between the two genders. Even if there was a completed study, and it had positive results -- it would be up against the social order of doctors -- who would find it a clear and present danger to their profession.