I've never experienced edema from any med, including regular and extended release Seroquel, and have taken doses up to 800 mg per day. I've taken at least 500 mg Seroquel XR for at least six years now.

I don't know what medication would ease edema. Have you seen a GP about that?

I've taken a number of moodstabilizers and antipsychotics over the years. Some were a little more side effect friendly than others. Your doctor will surely have some suggestions for you. Some I've taken were a bit more helpful for mania than depression, and vice versa.

My gut tells me you might want to steer clear of Lithium if you're prone to edema, but I may be totally wrong about that. I only write that because Lithium is the only bipolar med I've really read causes edema in a notable number of people.