So yesterday I started amitriptyline 25mg for agitated/anxious depression. It made feel stoned and my anxiety/panic and feeling of dread worse, and I woke in the middle of the night; aside from that I slept quite deeply with no dreams.

Today I still feel a bit anxious/feeling of dread but I think my actual mood is better (could be placebo).

Is this a bad sign? Or what I've seen called 'start up effects'?